Both sugary and artificially sweetened drinks are associated with a higher risk of developing liver disease, according to a study presented at the United European Gastroenterology (UEG) Week 25 meeting (abstract OP161). 

For the study, the researchers analyzed data from more than 120,000 UK Biobank participants. They found associations between regular consumption of both types of beverages and an increased risk of metabolic dysfunction–associated steatotic liver disease (MASLD), the most common chronic liver condition worldwide.

Specifically, the researchers followed 123,788 adults without liver disease at baseline over a median period of 10.3 years. Participants reported their beverage intake through repeated 24-hour dietary questionnaires. Those who drank more than 250 g per day (roughly one can) of low- or non-sugar-sweetened beverages (LNSSBs), had a 60% higher risk of developing MASLD. Furthermore, high consumers of sugar-sweetened beverages (SSBs) had a 50% higher risk.

Although both drink types were associated with increased liver fat accumulation, only LNSSB consumption was significantly linked to more liver-related deaths.

Water turned out to be the healthiest choice. Replacing these beverages with water lowered the risk of MASLD by 12.8% for sugary drinks and 15.2% for diet drinks. Switching between the two showed no benefit.

To access UEG WEEK 2025, click here; to access a news story on the presentation, click here